JAK and MEK Pathways as Therapeutic Targets for Saphenous Vein Smooth Muscle Cell Dysfunction in Type 2 Diabetes via Regulation of Mitochondrial Activity
Israel Olapeju Bolanle, Florah Tshepo Moshapa, Gillian A. Durham, James Hobkirk, Kirsten Riches‐Suman, Mahmoud Loubani, Roger G. Sturmey, Timothy M. Palmer
This study identifies JAK/STAT and MAPK/ERK pathways as regulators of mitochondrial dysfunction in HSVSMCs from T2DM patients, suggesting therapeutic targets for preventing saphenous vein graft failure.
bioRxiv · Oct 17, 2025 · PreprintCell Biology