Goliath clades and in vivo tracking of clonal dynamics show three phases of UV-induced skin carcinogenesis
Stanislav S. Avdieiev, Leticia Tordesillas, Karol Prieto, Omar Chavez Chiang, Zhihua Chen, Nihir Patel, Sofia Silva Simoes, Luiza Silva Simoes, Y. Ann Chen, Noemi Andor, Robert A. Gatenby, Elsa Renee Flores, Christopher J. Whelan, Joel S. Brown, Kenneth Yee Tsai
This study identifies three phases of UV-induced skin carcinogenesis using a mouse model, showing the emergence of large clades, clonal selection, and lesion formation.
Cancer Research · Sep 18, 2026Peer-reviewedCancer Biology