Elsa Renee Flores

The paper shows cancer cells in the lung take up cysteine and cystine efficiently, and the reduced tumor microenvironment supports their growth and resistance to oxidative stress.

This study identifies three phases of UV-induced skin carcinogenesis using a mouse model, showing the emergence of large clades, clonal selection, and lesion formation.

spatialMET provides a scalable, open-source framework for end-to-end spatial metabolomics analysis, identifying spatial domains and differential metabolites in mouse cancer data.

The paper develops microtumor models from lung cancer samples to study EMT and metabolic changes, identifying fatty acid synthesis as a targetable vulnerability.

This study identifies TROLL-8 as a regulator of fatty acid oxidation in breast cancer, showing its role in promoting tumorigenesis through CPT1A interaction.

This study identifies QPRT as a non-canonical apoptosis regulator in NSCLC that suppresses caspase-3 activation, independent of its role in NAD biosynthesis, suggesting it as a therapeutic target.

This study uses metal-organic framework nanoparticles to deliver antisense oligonucleotides, enhancing their stability and reducing PD-L1 expression in cancer cells.

iModMix identifies novel multi-omics associations by constructing data-driven modules without relying on biological annotations.

This study shows TAp73 regulates lipid metabolism in lung tumor microenvironment to enhance anti-tumor immunity through T-cell activation.

EnrichMET provides an R package for fast and reproducible pathway enrichment analysis in metabolomics, supporting multiple methods and offering both command-line and Shiny interfaces.

This study uses single-cell RNA-sequencing to show that aging promotes KRAS-driven lung adenocarcinoma evolution toward a stem-like state through age-related changes in the tumor microenvironment.