This study shows that a flexible decellularized dermis can be vascularized around a single vein, with fibroblasts enhancing vascularization, and demonstrates improved vascular outcomes compared to subcutaneous implantation.

bioRxiv · Oct 2, 2026 · PreprintBioengineering

Human nasal olfactory stem cell-derived extracellular vesicles improve the repair of rat nerves

Maxime Bonnet, Mostafa Seblani, Marie Witters, Tanguy Marqueste, Charlotte Jaloux, Philippe Morando, Patrick Decherchi, Francois pierre Feron, Gaëlle Guiraudie-Capraz

This study shows that human nasal olfactory stem cell-derived extracellular vesicles improve nerve repair in rats by enhancing locomotor recovery, muscle function, and axon regeneration.

Tissue Engineering and Regenerative Medicine · Jul 29, 2025Peer-reviewedNeuroscience

Culture of human nasal olfactory stem cells and their extracellular vesicles as advanced therapy medicinal products

Charlotte Jaloux, Maxime Bonnet, Marie Vogtensperger, Marie Witters, Julie Véran, Laurent Giraudo, Florence Sabatier, Justin Michel, Romaric Lacroix, Corinne Chareyre, Regis Legré, Gaëlle Guiraudie-Capraz, Francois pierre Feron

The paper develops a clinical-grade manufacturing protocol for olfactory stem cells and their extracellular vesicles, validated using nasal mucosa biopsies and demonstrating neurogenic properties in vitro.

bioRxiv · Aug 5, 2022 · PreprintNeuroscience