TAS1R3 regulates GTPase signaling in human skeletal muscle cells for glucose uptake.
Joseph M. Hoolachan, Rekha Balakrishnan, Karla Elzein Merz, Debbie C. Thurmond, Rajakrishnan Veluthakal
This study shows TAS1R3 regulates glucose uptake in skeletal muscle via a Rac1 and phospho-cofilin pathway, independent of IRS1-AKT and Galphaq/11, and identifies it as a potential therapeutic target for T2D.
International Journal of Molecular Sciences · Dec 22, 2025Peer-reviewedCell Biology