Debbie C. Thurmond

This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.

This study shows that harmine plus exendin-4, when combined with anti-CD3 therapy, promotes beta-cell recovery and reduces immunogenicity, leading to remission of recent-onset type 1 diabetes.

The paper identifies DOC2B decline as an early biomarker of presymptomatic type 1 diabetes progression, preceding traditional markers like C-peptide and HbA1c.

This study shows TAS1R3 regulates glucose uptake in skeletal muscle via a Rac1 and phospho-cofilin pathway, independent of IRS1-AKT and Galphaq/11, and identifies it as a potential therapeutic target for T2D.

This study shows STX4 is essential for mitochondrial homeostasis in skeletal muscle by regulating mitochondrial biogenesis and mitophagy.

This paper identifies a brown adipose tissue-secreted protein fraction that improves glycemia in T1D mice independently of insulin, with nidogen-2 as a key component that inhibits glucagon secretion.