Author

Jesús A. Izaguirre

ORCID 0000-0002-4687-4884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

Asghar M. RazaviiD· 1 shared Cheryl M. KohiD· 1 shared Fabio TrovatoiD· 1 shared Huafeng XuiD· 1 shared Timothy PalpantiD· 1 shared Yujie WuiD· 1 shared Zachary A. McDarghiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Asghar M. RazaviORCID

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1 paper

Recent·Most cited

Discovery of molecular glues by modeling ternary complex conformational ensembles and thermodynamic stability

Jesús A. Izaguirre, Zachary A. McDargh, Fabio Trovato, Yujie Wu, Timothy Palpant, Asghar M. Razavi, Cheryl M. Koh, Huafeng Xu

This paper introduces GlueMap, a computational platform for discovering molecular glues by integrating structural modeling and machine learning, showing improved performance over existing models in predicting degradation potency and identifying new degraders.

bioRxiv · Jan 13, 2025 · PreprintBioinformatics