Zachary A. McDargh

This study investigates why rod-shaped fusogens are common across eukaryotic and viral systems, showing that their rod shape generates entropic forces that drive membrane fusion efficiently.

This paper introduces GlueMap, a computational platform for discovering molecular glues by integrating structural modeling and machine learning, showing improved performance over existing models in predicting degradation potency and identifying new degraders.

The paper combines mathematical modeling and experiments to show Synaptotagmin rings act as Ca2+-sensitive fusion clamps and docking sensors in synaptic vesicle release.

The paper uses molecular dynamics simulations to show that SNAREs and Synaptotagmin work in fixed stoichiometry modules to determine Ca2+ sensitivity of neurotransmitter release.

This study uses simulations to show that Ca2+-triggered unclamping and SNARE-mediated fusion in neurotransmitter release are coupled processes, not sequential steps.