Yoji Kojima

scEGOT is a single-cell trajectory inference framework that identifies cell populations and segregation events in time-series scRNA-seq data, revealing key transcription factors involved in PGCLC differentiation.

This paper introduces RECODE, a noise reduction method for scRNA-seq data that eliminates the curse of dimensionality, improves cell clustering, and recovers gene expression for all genes.

This study shows that naive human pluripotent stem cells can recapitulate trophoblast development in vitro, producing cells that resemble human placental trophoblasts.