Yasuhiro Takashima

This paper identifies miR-98-5p as a let-7 family microRNA that enhances naive human PSC induction by repressing NR6A1 and activating BMP2/4 signaling, improving resetting efficiency to ~80%.

This study identifies EIF3D as a key regulator of primed pluripotency through selective translational control of signaling pathways and p53 regulators.

This study generates marmoset PGCLCs from iPSCs using mRNA transfection and shows their differentiation into gonocyte-like cells in xenoreconstituted testes.

This paper introduces CloneSelect, a multi-kingdom genetic barcoding system that enables precise isolation of target clones using CRISPR base editing to trigger reporter gene expression.

This study shows that inhibiting N-myristoyltransferase (Nmt) promotes naive pluripotency in both mouse and human pluripotent stem cells.

This study shows that naive human pluripotent stem cells can recapitulate trophoblast development in vitro, producing cells that resemble human placental trophoblasts.