Dicloxacillin and flucloxacillin inhibit hepatic uptake transporters - in vitro investigations and physiological based pharmacokinetic modelling
Noora Sjöstedt, Ogochukwu Ukamaka Amaeze, Jeroen J. M. W. van den Heuvel, Tore Bjerregaard Stage, Jan B. Koenderink, Nina Isoherranen, Heidi Kidron, Erkka Järvinen
This study investigates how dicloxacillin and flucloxacillin inhibit hepatic and renal transporters in vitro and uses PBPK modeling to assess clinical relevance.
Clinical and Translational Science · Feb 1, 2026Peer-reviewedPharmacology & Toxicology