Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
Charlotte S. R. Taylor, Jacco G. Renström, Joanna Loayza, Miriam Gwilt, Stuart A. Williams, Rachel Grasmeder Allen, Paula M. Moran, John Gigg, Joanna Caroline Neill, Michael Harte, Tobias Bast
This study investigates the role of GABAergic inhibition in the hippocampus and prefrontal cortex on novel object recognition in rats, finding that hippocampal inhibition is critical while prefrontal inhibition is not.
Journal of Neuroscience · Nov 4, 2025Peer-reviewedNeuroscience