Anthony Christopher Vernon

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons

This study investigates the role of ZNF804A in human neurodevelopment, finding it regulates excitatory synapse formation through increased local protein translation in developing cortical glutamatergic neurons.

A human neuron-microglia tri-culture platform to study the influence of microglia on developing neuronal networks in vitro

This paper develops a human neuron-microglia tri-culture platform to study cell-cell interactions during cortical development and disease modeling.

Electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines

This study examines electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines, showing increasing connectivity and plasticity over time.

Transcriptional and Cellular Response of hiPSC-derived Microglia-Neural Progenitor Co-Cultures Exposed to IL-6

The paper investigates how IL-6 exposure affects hiPSC-derived microglia-neural progenitor co-cultures, finding minimal transcriptional response in NPCs despite MGLs secreting IL-6R.

Individual behavioral trajectories shape whole-brain connectivity in mice

The paper shows that different behavioral patterns in mice lead to distinct brain connectivity patterns in an enriched environment.

Tissue Optimisation Strategies for High Quality Ex Vivo Diffusion Imaging

This paper develops an optimization strategy for ex vivo diffusion imaging in rodent brains to improve signal-to-noise ratio and reduce acquisition time.

A role for thalamic projection GABAergic neurons in circadian responses to light

This study identifies the role of thalamic GABAergic neurons in circadian responses to light, showing their involvement in vigilance state transitions and dim light entrainment.

Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells.

The paper shows that acute IL-6 exposure activates canonical IL-6R signaling in hiPSC-derived microglia but not neural progenitor cells, with implications for neurodevelopmental disorders.

A new cortical parcellation based on systematic review of primate anatomical tracing studies on corticostriatal projections

This paper develops a new human cortical parcellation atlas based on primate anatomical tracing studies and validates it using diffusion tractography to identify corticostriatal subcircuits.

Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells

The paper shows that schizophrenia hiPSC-derived NPCs have a reduced transcriptional response to IFN-gamma compared to controls, with implications for synaptic development and mitochondrial genes.

A unique cerebellar pattern of microglia activation in a mousemodel of encephalopathy of prematurity

This study investigates the effects of perinatal inflammation on cerebellar development in a mouse model of encephalopathy of prematurity, finding unique microglia activation and type I interferon signaling dysregulation in the cerebellum.

Erbb4 deletion from fast-spiking interneurons causes psychosis-relevant neuroimaging phenotypes

This study shows that deleting Erbb4 from PV+ interneurons in mice leads to neuroimaging changes similar to those seen in psychosis patients.

Interferon-γ Exposure of Human iPSC-derived Neurons Alters Major Histocompatibility Complex I and Synapsin I Protein Expression

This study shows that IFN-γ exposure in human iPSC-derived neurons increases MHCI and C4A expression while decreasing synapsin I protein, suggesting a role in neurodevelopmental disorders.

GABAA and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia

This study examines GABAA and NMDA receptor density changes in MAM-treated rats and their behavioral correlates, finding reduced 5GABAAR and increased NMDA receptor densities linked to schizophrenia-like behaviors.

MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in ALS-FTD

This study uses MRI and histology to identify structural and cellular changes in TDP-43 knock-in mice, linking them to ALS-FTD pathology and identifying PV+ interneuron loss as a potential biomarker.

Application of Airy beam Light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids

This paper optimizes Airy-beam light sheet microscopy to image 3D structures in hiPSC-derived human cortical spheroids, enabling high-resolution analysis of neurodevelopmental processes.

Region-specific and dose-specific effects of chronic haloperidol exposure on Ro15-4513 GABA-A receptor binding sites in the rat brain

This study shows chronic haloperidol increases [3H]-Ro15-4513 binding in rat hippocampus and [3H]-flumazenil binding across brain regions, suggesting antipsychotics may affect GABAAR availability.

Contrasting effects of chronic lithium, haloperidol and olanzapine exposure on synaptic clusters in the rat prefrontal cortex

This study examines the effects of chronic lithium, haloperidol, and olanzapine on synaptic markers in rat prefrontal cortex, finding lithium increases NLGN clusters while antipsychotics have no effect.

Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cells

This study identifies NT5C2 as a psychiatric risk gene, showing its role in protein translation and AMPK signaling in neural progenitor cells and Drosophila melanogaster.

Preliminary evidence that maternal immune activation specifically increases diagonal domain volume in the rat brain during early postnatal development

This study shows that maternal immune activation increases the volume of the diagonal domain in rat brains during early postnatal development, with potential sex differences.