Author

Xiaoqing Huang

National Institutes of HealthORCID 0000-0002-4711-6903Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-exome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Damian WójtowicziD· 2 shared Teresa M. PrzytyckaiD· 2 shared Bowang CheniD· 1 shared Itay Sason· 1 shared Mark D.M. LeisersoniD· 1 shared Martin C. S. WongiD· 1 shared Roded SharaniD· 1 shared Xiaoyun HuangiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 18 mutual co-author links

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2 shared papersBioinformatics

Damian WójtowiczORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pan-Cancer Driver Mutation Signatures Define a Molecular Taxonomy of Tumors

Xiaoyun Huang, Bowang Chen, Xiaoqing Huang, Martin C. S. Wong

This paper defines driver mutation signatures across cancers to classify tumors molecularly and link driver mutations to therapeutic vulnerabilities.

bioRxiv · Jun 18, 2026 · PreprintCancer Biology

Hidden Markov Models Lead to Higher Resolution Maps of Mutation Signature Activity in Cancer

Xiaoqing Huang, Itay Sason, Damian Wójtowicz, Yoo-Ah Kim, Mark D.M. Leiserson, Teresa M. Przytycka, Roded Sharan

This paper introduces sequence-dependent models for mutation signatures, improving the resolution of mutation signature activity in cancer by accounting for dependencies between mutations.

Genome Medicine · Jul 26, 2019Peer-reviewedBioinformatics

Detecting Presence Of Mutational Signatures In Cancer With Confidence

Xiaoqing Huang, Damian Wójtowicz, Teresa M. Przytycka

The paper assesses confidence and stability in decomposing mutational signatures in breast cancer genomes and identifies stable, unstable, and previously missed signatures.

Bioinformatics · Sep 21, 2017Peer-reviewedBioinformatics