Xiaoyun Huang

Pan-Cancer Driver Mutation Signatures Define a Molecular Taxonomy of Tumors

This paper defines driver mutation signatures across cancers to classify tumors molecularly and link driver mutations to therapeutic vulnerabilities.

multiMiAT: An optimal microbiome-based association test for multicategory phenotypes

The paper introduces multiMiAT, a microbiome-based association test for multicategory phenotypes, showing it performs well in simulations and real data analyses.

BNIP3 upregulation characterizes cancer cell subpopulation with increased fitness and proliferation

The paper identifies BNIP3 upregulation in cancer cell subpopulations associated with increased fitness and proliferation using single-cell data and organoid models.

Patient stratification of clear cell renal cell carcinoma using the global transcription factor activity landscape derived from RNA-seq data

This study stratifies clear cell renal cell carcinoma patients using transcription factor activity derived from RNA-seq data to predict prognosis and identify subtypes with distinct biomarkers and pathways.

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

This study identifies IL1β as an amplifier of IFN-induced antiviral responses through mathematical modeling and experimental validation.

Initial data release and announcement of the Fish10K: Fish 10,000 Genomes Project

The paper announces the Fish10K project to sequence 10,000 fish genomes and describes a workflow for biospecimen procurement, sequencing, and assembly.

The genome of Mekong tiger perch (Datnioides undecimradiatus) provides insights into the phylogenic position of Lobotiformes and biological conservation

The paper reports the first whole genome sequence of Mekong tiger perch, resolving phylogenetic relationships and providing insights into its demographic history and conservation.

Chromosome-level genome assembly of the African pike, Hepsetus odoe

This study presents a chromosome-level genome assembly of the African pike, Hepsetus odoe, using long-read and Hi-C sequencing technologies, providing a resource for evolutionary and functional studies.

Three genomes of Osteoglossidae shed light on ancient teleost evolution

This study presents three Osteoglossidae genomes to explore ancient teleost evolution, revealing divergence times and genomic changes linked to continental drift and dietary adaptations.

Draft genome of a porcupinefish, Diodon Holocanthus

This paper presents the first de novo genome assembly of the porcupinefish, Diodon holocanthus, using long-read sequencing technologies and provides annotations of repetitive sequences and protein-coding genes.

Chromosome-level genome assembly of a butterflyfish, Chelmon rostratus

This study presents the first chromosome-level genome assembly of the copperband butterflyfish, Chelmon rostratus, providing insights into genome evolution and adaptation in coral reef fish.

Comparative analysis of sequencing technologies platforms for single-cell transcriptomics

This study compares the sensitivity and accuracy of the BGISEQ-500 and Illumina HiSeq platforms for single-cell RNA sequencing using a standardized resource of 468 unique single-cells and 1,297 matched single cDNA samples.