Molecular BiologybioRxivPreprint
Disruption of the VEGFR3-HSPG2 induces lymphatic reflux dysfunction and sepsis
Yiming Zhang, Linfeng Liu, Wei Guo…·金胜威
The paper identifies lymphatic reflux dysfunction as a driver of sepsis by showing that VEGFR3-SOX18-HSPG2-heparan sulfate disruption impairs lymphatic barrier function and promotes systemic inflammation.
DOI 10.64898/2026.01.28.702461