Unique RNA replication characteristics and nucleocapsid protein expression may explain differences in the replication capacity of SARS-COV-2 lineages.
Isadora Alonso Corrêa, Marcos Romário Matos de Souza, Gustavo Peixoto Duarte da Silva, Anna Beatriz Sampaio Vianna Macedo Pimentel, Pedro Telles Calil, Marcela Sabino Cunha, Diana Mariani, Rodrigo de Moares Brindeiro, Sara Mesquita Costa, Maria Clara da Costa Simas, Victor Akira Ota, Elisa Cavalcante Pereira, Marilda Mendonça Siqueira, Paola Cristina Resende, Rafael Mello Galliez, , Luciana Jesus da Costa
This study compares replication capacity and nucleocapsid proteoforms across SARS-CoV-2 variants in human pulmonary cells, finding Omicron BA.1 has reduced replication and variant-specific proteoforms.
Frontiers in Cellular and Infection Microbiology · Jul 11, 2025Peer-reviewedMicrobiology