Author

K. Lenhard Rudolph

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)ORCID 0000-0002-4839-2862Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:ATAC-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Organism:plant (other)· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adam L. MacLeaniD· 1 shared Alessandra SalvettiiD· 1 shared Andreas KoeberleiD· 1 shared Anne Thems· 1 shared Astrid S. Pfister· 1 shared Cristina González‐EstéveziD· 1 shared Daniel A. Felix· 1 shared Elias Moris AmroiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperSystems Biology

Adam L. MacLeanORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintApr 18, 2023

Gene regulatory network inference with popInfer reveals dynamic regulation of hematopoietic stem cell quiescence upon diet restriction and aging

Megan K. Rommelfanger, Marthe Behrends, Yulin Chen…·Adam L. MacLean

This study introduces popInfer, a method for inferring gene regulatory networks from single-cell multiomics data, and applies it to uncover dynamic regulation of hematopoietic stem cell quiescence in mice under different dietary and aging conditions.

2 citations

𝕏 PostBluesky

Developmental BiologyEMBO ReportsPeer-reviewedJun 30, 2021

TRiC activates the unfolded protein response and protects starved stem cells by modulating energy and lipid metabolism during planarian regeneration

Óscar Gutiérrez‐Gutiérrez, Daniel A. Felix, Alessandra Salvetti…·Cristina González‐Estévez

This study identifies TRiC's role in maintaining stem cell function during planarian starvation by activating the UPR and regulating energy and lipid metabolism.

8 citations

plant (other)experimental assay

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BioinformaticsbioRxivPreprintSep 30, 2020

Dynamic characteristics rather than static hubs are important in biological networks

Silke D Werle, Nensi Ikonomi, Julian D. Schwab…·Hans Armin Kestler

The paper identifies minimal node sets that determine network dynamics, finding that dynamic decision-makers are not static hubs.

DOI 10.1101/2020.09.30.320259

statistical model

𝕏 PostBluesky