Author

Shelby S. Darnell

University of Tennessee Health Science CenterORCID 0000-0002-4841-4398Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Organism:human· 1 Approach:large language model· 1 Organism:mouse· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Erik P. GarrisoniD· 2 shared G. Edward SuhiD· 2 shared Pengzhi HuangiD· 2 shared Pjotr PrinsiD· 2 shared Adrian Kibet· 1 shared Alexander Kabui· 1 shared Andrea GuarracinoiD· 1 shared Arun IsaaciD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Erik P. GarrisonORCID

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2 papers

Recent·Most cited

Pangenome-Informed Language Models for Synthetic Genome Sequence Generation

Pengzhi Huang, François Charton, Jan-Niklas M. Schmelzle, Shelby S. Darnell, Pjotr Prins, Erik P. Garrison, G. Edward Suh

This paper introduces pangenome-informed language models for generating synthetic DNA sequences, showing improved efficiency and quality over classical methods.

IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · Dec 15, 2025Peer-reviewedBioinformatics

Creating a biomedical knowledge base by addressing GPT inaccurate responses and benchmarking context

Shelby S. Darnell, Rupert W. Overall, Andrea Guarracino, Vicenza Colonna, Flavia Villani, Erik P. Garrison, Arun Isaac, Priscilla Muli, Muriithi Frederick Muriuki, Alexander Kabui, Munyoki Kilyungi, Felix Lisso, Adrian Kibet, Brian Muhia, Harm Nijveen, , Pjotr Prins

GNQA, a retrieval-augmented GPT question-answering system over 3000 GeneNetwork, aging and diabetes papers, cites source paragraphs; RAGAS rated answer relevance above human thumbs-up ratings (89% vs 76%).

Open Research Africa · Sep 2, 2025Peer-reviewedScientific Communication & Education✦ In-depth digest