Rupert W. Overall

The paper identifies the Pgb1 locus as controlling glycogen aggregation in aged hippocampal astrocytes without affecting cognitive function.

The paper describes the development and evaluation of an agentic framework using LLMs to explore molecular interaction maps through user-driven prototyping and testing.

GNQA, a retrieval-augmented GPT question-answering system over 3000 GeneNetwork, aging and diabetes papers, cites source paragraphs; RAGAS rated answer relevance above human thumbs-up ratings (89% vs 76%).

This study identifies Apbb1ip as a genetic modulator of immune gene co-expression in aged mouse hippocampus, revealing age-related transcriptomic changes and immune response upregulation.

This study investigates how social environment affects Alzheimer's disease progression in App-NL-G-F mice, showing social deficits precede pathology and linking microglia activation to neuroinflammation and neurogenesis.

The paper presents a computational framework for analyzing SARS-CoV-2-host interactions to identify drug targets and model disease mechanisms.

The paper describes the development of a computational knowledge repository, the COVID-19 Disease Map, which curates SARS-CoV-2 virus-host interaction mechanisms and provides tools for their analysis and application.

This study shows environmental enrichment counteracts age-related DNA methylation changes in the hippocampus of mice, preventing CpG hypomethylation at Mecp2 target sites and preserving neuronal functions.

The paper identifies Tti2 as a gene influencing both adult hippocampal neurogenesis and serum glucose levels using a rat genetic model.

This study identifies pro-neurogenic compounds in apple peel and flesh that enhance hippocampal neurogenesis in adult mice through distinct mechanisms.

The paper identifies high ROS levels in quiescent adult hippocampal stem cells and shows how physical activity triggers their activation through a Nox2-dependent ROS surge.

This study shows that early-life environmental enrichment in mice leads to persistent individualized behaviors and lasting epigenetic changes in the hippocampus.