Mechanoreceptor Piezo1-Mediated Interleukin Expression in Conjunctival Epithelial Cells: Linking Mechanical Stress to Ocular Inflammation
Seiya Fukuoka, Naoki Adachi, Erika Ouchi, Hideshi Ikemoto, Takayuki Okumo, Fumihiro Ishikawa, Hidetoshi Onda, Masataka Sunagawa
This study shows that Piezo1 channel activation in conjunctival epithelial cells increases IL-6 and IL-8 expression through the p38 MAPK-CREB pathway, linking mechanical stress to ocular inflammation.
The Ocular Surface · Jan 6, 2025Peer-reviewedPhysiology