This study performs a systematic review and meta-analysis of pharmacological and stress-related interventions on social behavior in adult zebrafish, finding inconsistent effects and methodological limitations.

bioRxiv · May 29, 2026 · PreprintNeuroscience

Effects of NMDA antagonists on social behaviour: a systematic review and meta-analysis of preclinical studies

Matheus Gallas‐Lopes, Mariana B. Abreu, Michael Andrades, Bruno Dutra Arbo, Leonardo M. Bastos, Tainah C. Caetano, Daniela Virote Kassick Müller, A. Pimenta Alves, Daniel Alves Rosa, Dirson João Stein, Ana P. Herrmann

This study reviews and analyzes preclinical data on NMDA antagonists' effects on social behavior, finding reduced social interaction and preference, with mixed effects of antipsychotics.

bioRxiv · May 15, 2026 · PreprintPharmacology & Toxicology

Estimating the replicability of Brazilian biomedical science

The Brazilian Reproducibility Initiative, Olavo B. Amaral, Clarissa F. D. Carneiro, Kleber Neves, Ana Paula Wasilewska‐Sampaio, Bruna Valério‐Gomes, Mariana Boechat de Abreu, Pedro Batista Tan, Gabriel Paz Souza Mota, Ricardo Netto Goulart, Nathalia Raquel de Souza Fernandes, Jimmy Hayden Linhares, A. M. G. Ibelli, Adriano Defini Andricopulo, Adriano Sebollela, , Igor L. Baptista

In validated multicenter replications, 20 to 44% of 45 published Brazilian MTT, RT-PCR and elevated plus maze experiments replicated, depending on criterion; replication effects were usually smaller.

bioRxiv · Apr 2, 2025 · PreprintScientific Communication & Education✦ In-depth digest