Adriano Sebollela

The human neuroblastoma SH-SY5Y cell line as a model to assess β-amyloid neurotoxicity: A systematic review and meta-analysis

This paper reviews and analyzes 359 studies on β-amyloid toxicity in SH-SY5Y cells, finding that toxicity depends on Aβ concentration, exposure time, and aggregation state, not cell differentiation.

Estimating the replicability of Brazilian biomedical science

In validated multicenter replications, 20 to 44% of 45 published Brazilian MTT, RT-PCR and elevated plus maze experiments replicated, depending on criterion; replication effects were usually smaller.

AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models

This study shows that AAV-delivered scFv antibodies targeting Aβ oligomers protect synapses and rescue memory in Alzheimer's disease models.