BiophysicsbioRxivPreprint
A widespread protein misfolding mechanism is differentially rescued by chaperones based on gene essentiality
Ian M. Sitarik, Quyen V. Vu, Justin Petucci…·Edward P. O’Brien
The paper identifies a widespread protein misfolding mechanism involving non-covalent lasso entanglement (NCLE) and shows that chaperones rescue it more effectively for essential proteins.
DOI 10.1101/2025.09.18.677077