Ian M. Sitarik

Natively entangled proteins are linked to human disease and pathogenic mutations likely due to a greater misfolding propensity

The paper investigates whether proteins with native entanglements are more prone to misfolding and associated with disease, finding significant statistical associations.

Detecting misfolded non-covalent lasso entanglements in protein structures, simulation trajectories, and mass spectrometry data

The paper introduces EntDetect, a tool to detect non-covalent lasso entanglements in protein structures, simulations, and mass spectrometry data, and demonstrates its application in identifying misfolded states.

Native entanglement misfolding contributes to age-associated structural changes across the Saccharomyces cerevisiae proteome

The paper examines age-related structural changes in yeast proteins using mass spectrometry and simulations, finding that entanglement misfolding contributes to proteome aging.

A widespread protein misfolding mechanism is differentially rescued by chaperones based on gene essentiality

The paper identifies a widespread protein misfolding mechanism involving non-covalent lasso entanglement (NCLE) and shows that chaperones rescue it more effectively for essential proteins.