Author

William K. Corcoran

Northwestern UniversityORCID 0000-0002-4959-2727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Joshua N. LeonardiD· 4 shared Amparo CosioiD· 2 shared Hailey I. EdelsteiniD· 2 shared Taylor B. DolbergiD· 2 shared Aaron H. MorrisiD· 1 shared Alexis N. PrybutokiD· 1 shared Anthony MegeriD· 1 shared David Z. BushhouseiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersSynthetic Biology

Joshua N. LeonardORCID

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4 papers

Recent·Most cited

Synthetic BiologyNature Chemical BiologyPeer-reviewedAug 22, 2025

Conversion of natural cytokine receptors into orthogonal synthetic biosensors

Hailey I. Edelstein, Amparo Cosio, Max L. Ezekiel…·Joshua N. Leonard

The paper develops synthetic cytokine receptors by repurposing natural ectodomains to create orthogonal biosensors for targeted cellular responses.

11 citationstop 4%

experimental assay

𝕏 PostBluesky

Synthetic BiologyGEN BiotechnologyPeer-reviewedFeb 1, 2025

Exploring structure-function relationships in engineered receptor performance using computational structure prediction

William K. Corcoran, Amparo Cosio, Hailey I. Edelstein, Joshua N. Leonard

This study uses computational structure prediction to explore how structural features of engineered receptors relate to their functional performance.

4 citations

protein structurestatistical model

𝕏 PostBluesky

Molecular BiologyJournal of Molecular BiologyPeer-reviewedApr 1, 2021

RNA sequence and structure determinants of Pol III transcriptional termination in human cells

Matthew S. Verosloff, William K. Corcoran, Taylor B. Dolberg…·Julius B. Lucks

The paper develops an in cellulo assay to study Pol III transcription termination in human cells and identifies sequence and structural determinants for efficient termination.

10 citations

humanbulk RNA-seq

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Synthetic BiologyNature Chemical BiologyPeer-reviewedFeb 1, 2021

Computation-guided optimization of split protein systems

Taylor B. Dolberg, Anthony Meger, Jonathan D. Boucher…·Joshua N. Leonard

This paper presents a computational method to optimize split protein systems by guiding the evaluation of mutants to find an optimal functional window.

80 citationstop 4%

protein sequencestatistical model

𝕏 PostBluesky