Longitudinal MRI reveals hormone-dependent brain remodeling supporting preserved cognition in aged females
Egoa Ugarte Perez, Elena Espinós-Soler, Antonio Cerdán Cerdá, Aroa S. Maroto, Patricia Martínez-Tazo, Maximilian F. Eggl, Laura Pérez-Cervera, Santiago Canals, Silvia De Santis
This study uses longitudinal MRI and complementary techniques in rats to show that female-specific brain connectivity and white matter preservation support cognitive resilience with age, mediated by sex hormones.
bioRxiv · Apr 6, 2026 · PreprintNeuroscience