MEG3 Enhances Survival of Developing Human Neurons with CLCN4-Linked Autophagy Impairment
Dayeon Kim, Yongjun Koh, Hyeon Seong Jeong, Jaehyung Kim, Hyunsu Do, Geurim Son, Yeni Kim, Donghyuk Kim, Hyun–Ho Lim, Jong-Eun Park, Jinju Han
The paper identifies CLCN4 variants causing neuronal cell death and autophagy impairment, showing MEG3 restoration rescues these defects in human neurons.
bioRxiv · Jul 16, 2025 · PreprintNeuroscience