Hyun–Ho Lim

This study reports cryo-EM structures of two small protein-ligand complexes near the theoretical size limit of 38 kDa, demonstrating cryo-EM's utility for structure determination and drug screening.

This paper determines cryo-EM structures of an anti-MLC1 Fab in apo and peptide-bound states, revealing the structural basis of antigen recognition and demonstrating cryo-EM's capability for small Fab-antigen complexes.

The paper identifies CLCN4 variants causing neuronal cell death and autophagy impairment, showing MEG3 restoration rescues these defects in human neurons.

This study shows that Sema3E-Plexin-D1 signaling activates Mtss1 to coordinate axonal extension and steering during neuronal pathfinding.

The paper investigates the conformational states of Gluex in CLC-ec1 using crystal structures of mutants and wildtype under varying anion concentrations, suggesting three distinct intermediate states.