BioinformaticsbioRxivPreprint
SARS-CoV-2 ORF8 can fold into human factor 1 catalytic domain binding site on complement C3b: Predict functional mimicry
Jasdeep Singh, Sudeshna Kar, Seyed E. Hasnain, Surajit Ganguly
The paper models SARS-CoV-2 ORF8's structural similarity to human complement factor 1's C3b binding site and predicts it competes with F1 for C3b binding, potentially causing unregulated complement activation.
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