Fangzhou Xiao

This paper introduces flux-species sampling (FSS) to explore biocircuit behavior by directly sampling steady-state species and fluxes, improving the identification of regulatory modes and behavior-realizing regimes.

The paper designs a multimolecular proofreading circuit that overcomes the activity-fidelity trade-off in synthetic biological systems.

The paper evaluates parameter regimes for biocircuits using the Realizability Index (R-index) to quantify valid regions and demonstrates its application to kinetic models.

The paper challenges a previous conclusion about kinetic proofreading by showing that allowing discrimination time to vary can improve ligand discrimination with more proofreading steps.

This study extends the initiator-titration model to explain how bacteria control replication initiation through protein copy-number sensing, addressing two long-standing questions about DnaA overproduction and its active/inactive forms.

This work introduces log derivatives to analyze and design biomolecular circuits for robust stability and control through structural properties.

The paper introduces a theoretical framework for analyzing genetic circuit dynamics, focusing on structural properties to predict bistability and oscillations in biological systems.

This paper shows that coupling in reaction networks can suppress noise below a previously established lower bound with moderate energy cost.

The paper applies control theory to analyze and design sequestration feedback circuits, showing how to characterize their performance and tradeoffs.

This paper investigates the challenges of achieving robust perfect adaptation in biomolecular systems and shows how integral feedback control can be implemented through network architecture rather than direct dynamics.

The paper analyzes sequestration feedback systems using control theory to identify performance limits and tradeoffs in biological feedback mechanisms.

The paper develops Athlon, an algorithm for accurate class I HLA typing using Oxford Nanopore sequencing, achieving 100% accuracy in high-resolution typing.