Noah Olsman

Mapping Synthetic Circuit Design Space through Massively Parallel Measurement of Single-Cell Dynamics

The paper uses a high-throughput platform to measure single-cell dynamics of gene-regulatory circuits and maps their design space by testing robustness and identifying key interactions.

Inherited flagellar structures coordinate the onset of swimming among related E. coli cells

The paper shows how inherited flagellar structures coordinate swimming onset in E. coli cells by integrating transcriptional noise and sharpening it into a heritable decision.

Antithetic integral feedback for the robust control of monostable and oscillatory biomolecular circuits

The paper applies dominance analysis to study the behavior of antithetic integral feedback circuits, showing they can exhibit both monostability and oscillations depending on parameters.

Architectural Principles for Characterizing the Performance of Sequestration Feedback Networks

The paper applies control theory to analyze and design sequestration feedback circuits, showing how to characterize their performance and tradeoffs.

Design Guidelines For Sequestration Feedback Networks

This paper provides design guidelines for stable and effective sequestration feedback networks in synthetic biology.

Hard Limits And Performance Tradeoffs In A Class Of Sequestration Feedback Systems

The paper analyzes sequestration feedback systems using control theory to identify performance limits and tradeoffs in biological feedback mechanisms.