Guide-tree bias of whole genome alignment can mislead phylogenomic analyses
The paper shows guide-tree bias in whole-genome alignment can mislead phylogenomic analyses and proposes a consensus alignment strategy to reduce this bias.
Author
Chinese Academy of SciencesORCID 0000-0002-5037-8138Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
The paper shows guide-tree bias in whole-genome alignment can mislead phylogenomic analyses and proposes a consensus alignment strategy to reduce this bias.
TriMouNet infers level-1 phylogenetic networks from multi-locus gene tree distributions, identifying reticulations with low false positive rates when gene trees are accurate.
This paper introduces MLRE, a maximum-likelihood method for species tree reconstruction using low-homoplasy markers, showing improved performance on simulated data and better agreement with published Neoaves phylogenies.
Mengzhen Guo, Stefan Grünewald
Lpnet reconstructs phylogenetic networks from distances using integer linear programming, improving approximation accuracy over Neighbor-net for most datasets.
Yin Huang, Dan Li, Lu Qiao…·Stefan Grünewald
This study identifies five novel genetic loci associated with facial morphology traits in Han Chinese through a genome-wide association analysis of 3D facial data.
Weikang Gong, Lin Wan, Wenlian Lu…·Jianfeng Feng
This paper develops a statistical framework for connexel-wise analysis in brain-wide association studies, improving power and reducing false positives using spatial information from fMRI data.
Weikang Gong, Fan Cheng, Edmund T. Rolls…·Jianfeng Feng
This paper introduces sKPCR, a method for identifying voxel-phenotype associations in dense connectomes, showing better reproducibility and overlap with existing schizophrenia findings.