Jin Li

The paper introduces Plasmix, a plasma reference suite, to improve cross-platform proteomics integration by identifying proteins with consistent titration responses across platforms.

This paper introduces a geometric framework for agentic reasoning on curved manifolds, showing improved performance in a tissue repair task compared to flat-space methods.

The paper introduces a unified model for biological prediction that integrates geometry, mechanism, and causal structure, achieving lower error than Euclidean and local graph baselines in synthetic studies.

This study introduces LEAP, a method for estimating shared proteomic architectures across traits, finding 585 significant proteomic correlations among 50 traits using UK Biobank data.

The paper identifies novel structural variants in Han Chinese genomes using long-read sequencing and links them to phenotypic diversity and disease susceptibility.

The paper introduces Limpute, an efficient algorithm for genotyping common variants from low-coverage sequencing data, achieving high imputation accuracy with faster runtime than GLIMPSE2.

The paper identifies a lineage-specific super-enhancer for MYB in gastrointestinal adenocarcinoma and shows its role in regulating MYB expression and tumor development.

The paper identifies a human-specific mutation linked to height and basal metabolic rate, showing its evolutionary timing and functional impact through dietary changes.

This study identifies four genetic loci associated with hip morphology in Chinese populations through GWAS, with two loci previously linked to musculoskeletal development and two being novel findings.

This study investigates the relationship between lower genital tract microbiota and reproductive outcomes in PCOS patients, finding that higher Lactobacillus abundance correlates with better IVF-FET outcomes.

This paper introduces Quartet DNA reference materials to comprehensively evaluate germline variant calling accuracy across the genome, including difficult regions and batch effects.

This paper introduces ratio-based multiomics profiling using universal reference materials to improve data integration across omics types and batches.

The paper introduces RNA reference materials and ratio-based datasets to improve the reliability and benchmarking of transcriptomic profiling.

This paper presents a high-quality cattle genome assembly with improved continuity and completeness, revealing the highest known immune gene diversity in mammals.

This study identifies five novel genetic loci associated with facial morphology traits in Han Chinese through a genome-wide association analysis of 3D facial data.

This paper uses ancient and present-day genomic data to reconstruct the population history of East Asia, identifying key migrations and language dispersals.

This study identifies 24 genetic loci associated with facial shape variation in humans through GWAS and confirms 13 of them in a multi-ethnic cohort.

The paper analyzes genomic data from Hmong-Mien-speaking populations to reveal an inland-coastal genetic split linked to agricultural expansion in southern China.

This paper introduces a new statistical method for GWAS that improves power and reduces false positives by using large public databases as references.

The paper evaluates the antifibrotic effects of triple siRNA targeting SPARC, CCR2, and SMAD3 in a mouse model of fibrosis, showing reduced inflammation and fibrosis through multi-target intervention.

The paper identifies six genome-wide significant loci associated with facial shape differences between Europeans and Han Chinese and develops a DNA-based 3D face prediction model.

This study identifies epistatic interactions between PKD2 and ABCG2 influencing uric acid levels and gout risk, with gender and BMI-dependent effects.