Translating Brain Anatomy and Disease from Mouse to Human in Latent Gene Expression Space
Chloé Jaroszynski, Mohammed Amer, Antoine Beauchamp, Jason P. Lerch, Stamatios N. Sotiropoulos, Rogier B. Mars
This paper develops a VAE-based framework to translate mouse brain gene expression to human, showing that mouse disease models predict human Alzheimer's and Parkinson's patterns and identify the best mouse model for AD patients.
EBioMedicine · Apr 24, 2026Peer-reviewedNeuroscience