Jason P. Lerch

The paper examines cell type-specific sex effects on gene expression in autism and finds a stronger overlap with autism than schizophrenia.

This study uses longitudinal edited 1H-MRS to track GABA and glutamate changes after experimental stroke in rats, finding a transient GABA reduction without persistent inflammation or major behavioral impairment.

In 14 BXD mouse strains, those modelling developmental coordination disorder have relatively larger cortex and smaller cerebellar/subcortical volumes; this axis tracks motor coordination but maps to no single QTL.

This paper introduces POPE13C-MRS, a method to non-invasively measure neurotransmitter-specific glucose metabolism in the human brain using standard MRI hardware, demonstrating its feasibility in mice and humans.

The paper identifies a hippocampal metabolic signature linked to mood and insulin signalling in depression, showing conserved effects across humans and mice.

This paper develops a VAE-based framework to translate mouse brain gene expression to human, showing that mouse disease models predict human Alzheimer's and Parkinson's patterns and identify the best mouse model for AD patients.

The paper uses DyNeMo to analyze MEG data from children and adults during emotional face processing, revealing distinct developmental trajectories in brain network activation and connectivity.

This study uses MRI to show that ATRX deficiency in mice leads to brain structural changes linked to autism-like behaviors, including sex-specific microcephaly and altered hippocampal and cortical volumes.

This study identifies unique functional connectivity patterns in autism associated with five sensory processing phenotypes using machine learning.

The paper quantifies gonadal and sex chromosome dosage contributions to sex differences in brain volume across multiple regions in mice, revealing their combined effects on anatomical and cellular gene expression.

This study shows that enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction in a mouse model of SCA44.

The paper introduces dGAMLSS, a distributed algorithm for fitting GAMLSS models to construct population reference charts without sharing patient data.

The paper investigates the relative impact of gonads and sex chromosomes on sex differences in gene expression in the mouse medial septum and links these differences to sex-biased human diseases.

This study uses diffusion-weighted MRS to track cell-specific developmental trajectories in the cerebellum and thalamus of rat neonates, revealing age-related changes in metabolite diffusion properties.

The paper quantifies sex differences in human cortical volume by separating contributions from surface area and thickness, and links these to genetic and hormonal factors using neuroimaging data.

This study uses deep learning to predict internalizing problems from brain structure in youth, finding good performance in neurodevelopmental conditions but sub-optimal in the general population.

The paper examines multisensory integration network (MSN) functional connectivity in neurodevelopmental disorders and finds that sensory characteristics, not diagnoses, drive the observed neural patterns.

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

The paper investigates sex differences in anatomical covariance across humans and mice, finding stronger structural covariance in females and inverse relationships between volumetric sex biases and covariance patterns.

The paper identifies hypo- and hyperconnectivity subtypes in autism using cross-species fMRI, linking them to distinct biological mechanisms in mice and humans.

This study shows environmental enrichment during the perinatal period alters brain structure in mice by P7, with changes in hindbrain, dorsal striatum, and medial habenula, mediated by maternal care.

The paper identifies a brain-wide twisting asymmetry in mice, similar to human cerebral petalia, using data from 3,500 animals across six cohorts.

This study quantifies creatine kinase kinetics in mouse brain using 31P-MRS at 7 Tesla, showing that reduced breathing rate increases the forward rate constant by 36%.

The paper examines age-related changes in brain structure and function across two neurodiverse datasets, finding differences linked to demographic and clinical factors.

This study identifies hemispheric asymmetry in mouse brains, revealing species-specific patterns and differences from humans, with implications for autism research.

This study shows that KDM5B deficiency in mice leads to autism-like behaviors and increased brain size, which can be mitigated by NMDAR antagonists.

This study characterizes a mouse model with TDP-43 M323K mutation, showing cognitive, motor, and structural brain abnormalities linked to TDP-43 mislocalization and increased levels.

This study compares sex differences in brain anatomy between humans and mice using neuroimaging, finding partial conservation of volumetric sex differences in cortical regions.

This study examines thalamocortical structural covariance in mice, identifies six thalamic clusters, and shows their association with cortical connectivity and functional organization.