Author

Jose Alberto de la Paz

The University of Texas at DallasORCID 0000-0002-5053-4807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

Devin Meng· 1 shared Erdal ToprakiD· 1 shared Faruck MorcosiD· 1 shared Ilona Kamila GaszekiD· 1 shared Milo M. LiniD· 1 shared Muhammed Sadik YildiziD· 1 shared Sophia Maria AlvareziD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperEvolutionary Biology

Devin Meng

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1 paper

Recent·Most cited

Higher-order epistasis drives evolutionary unpredictability toward novel antibiotic resistance

Ilona Kamila Gaszek, Muhammed Sadik Yildiz, Devin Meng, Jose Alberto de la Paz, Sophia Maria Alvarez, Faruck Morcos, Milo M. Lin, Erdal Toprak

This study constructs a comprehensive mutant library of TEM-1 beta-lactamase and shows that higher-order epistasis drives unpredictable evolution of antibiotic resistance to novel substrates.

bioRxiv · Jul 8, 2025 · PreprintEvolutionary Biology