Muhammed Sadik Yildiz

This study maps how β-lactamase mutations confer resistance to different antibiotics, identifying generalist and specialist mutations with distinct mechanisms and positions.

This study constructs a comprehensive mutant library of TEM-1 beta-lactamase and shows that higher-order epistasis drives unpredictable evolution of antibiotic resistance to novel substrates.

This study investigates drug-drug interactions in AML cell lines, finding widespread but non-conserved synergistic and antagonistic effects across different cell lines.

The paper shows that sequential antibiotic treatment leads to convergent multidrug resistance through extinction of resistance mutations, with single-cell RNA sequencing revealing metabolic and translational state changes.