Single-Cell Transcriptomic Mapping of PD-L1/TLR4 Remodeling Informs Topical Immunoprevention Timing in Skin Carcinogenesis
Ran Wei, Rudramani Pokhrel, Delaney Stratton, Sara M. Centuori, Clara N. Curiel‐Lewandrowski, Georg T. Wondrak, Sally E. Dickinson, Bonnie LaFleur, Xiaoxiao Sun
This study uses single-cell RNA sequencing to identify immune remodeling stages in skin carcinogenesis, showing PD-L1/TLR4 signaling changes from sun-damaged to actinic keratosis stages, informing optimal timing for topical immunoprevention.
bioRxiv · Jun 4, 2026 · PreprintCancer Biology