Xiaoxiao Sun

This study uses single-cell RNA sequencing to identify immune remodeling stages in skin carcinogenesis, showing PD-L1/TLR4 signaling changes from sun-damaged to actinic keratosis stages, informing optimal timing for topical immunoprevention.

The paper introduces FAST, a reference-free deconvolution method for spatial transcriptomics data that integrates gene expression, spatial coordinates, and histology information, outperforming existing methods in simulations and real data.