Cancer BiologybioRxivPreprint
Single-Cell Transcriptomic Mapping of PD-L1/TLR4 Remodeling Informs Topical Immunoprevention Timing in Skin Carcinogenesis
Ran Wei, Rudramani Pokhrel, Delaney Stratton…·Xiaoxiao Sun
This study uses single-cell RNA sequencing to identify immune remodeling stages in skin carcinogenesis, showing PD-L1/TLR4 signaling changes from sun-damaged to actinic keratosis stages, informing optimal timing for topical immunoprevention.