Shivakumar Kailasam

Metformin attenuates hyperglycaemia-stimulated pro-fibrotic gene expression in vascular adventitial fibroblasts via inhibition of Discoidin Domain Receptor 2

This study shows metformin reduces DDR2-mediated fibrosis in vascular fibroblasts under hyperglycaemia by inhibiting TGF-β1/Smad2/3 signalling.

Discoidin Domain Receptor 2 regulates AT1R expression in Angiotensin II-stimulated cardiac fibroblasts via fibronectin-dependent Integrin-β1 signaling

This study identifies DDR2-mediated fibronectin regulation as a key mechanism for Angiotensin II-induced AT1R expression in cardiac fibroblasts through Integrin-β1 signaling.

Co-ordinated regulation of cell survival and cell cycle pathways by DDR2-dependent SRF transcription factor in cardiac fibroblasts

This study identifies DDR2-dependent SRF activation as a mechanism regulating cell survival and cell cycle progression in cardiac fibroblasts through ERK1/2 MAPK signaling.