Author

Harikrishnan Venugopal

Sree Chitra Thirunal Institute for Medical Sciences and TechnologyORCID 0000-0002-1277-3612Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:experimental assay· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Allen Sam TitusiD· 3 shared Shivakumar KailasamiD· 3 shared Edward G. LakattaiD· 2 shared Mereena George UshakumaryiD· 2 shared Mingyi WangiD· 2 shared Randy T. CowlingiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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3 shared papersMolecular Biology

Allen Sam TitusORCID

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3 papers

Recent·Most cited

Molecular BiologyInternational Journal of Molecular SciencesPeer-reviewedDec 29, 2022

Metformin attenuates hyperglycaemia-stimulated pro-fibrotic gene expression in vascular adventitial fibroblasts via inhibition of Discoidin Domain Receptor 2

Allen Sam Titus, Mereena George Ushakumary, Harikrishnan Venugopal…·Shivakumar Kailasam

This study shows metformin reduces DDR2-mediated fibrosis in vascular fibroblasts under hyperglycaemia by inhibiting TGF-β1/Smad2/3 signalling.

12 citations

statistical model

𝕏 PostBluesky

Molecular BiologyInternational Journal of Molecular SciencesPeer-reviewedAug 28, 2021

Discoidin Domain Receptor 2 regulates AT1R expression in Angiotensin II-stimulated cardiac fibroblasts via fibronectin-dependent Integrin-β1 signaling

Allen Sam Titus, Harikrishnan Venugopal, Mereena George Ushakumary…·Shivakumar Kailasam

This study identifies DDR2-mediated fibronectin regulation as a key mechanism for Angiotensin II-induced AT1R expression in cardiac fibroblasts through Integrin-β1 signaling.

13 citations

mouseexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintApr 21, 2020

Co-ordinated regulation of cell survival and cell cycle pathways by DDR2-dependent SRF transcription factor in cardiac fibroblasts

Allen Sam Titus, Harikrishnan Venugopal, Shivakumar Kailasam

This study identifies DDR2-dependent SRF activation as a mechanism regulating cell survival and cell cycle progression in cardiac fibroblasts through ERK1/2 MAPK signaling.

DOI 10.1101/857037

ratstatistical model

𝕏 PostBluesky