Michael Wilkinson

The paper analyzes ambigrammatic narnavirus genomes to test hypotheses about functional protein coding in reverse open reading frames.

The paper analyzes single-cell mRNA counts from adult mouse tissues to show that gene expression is often intermittent rather than restricted to specific cell types, with peak transcription levels consistent across tissues but varying probabilities of activity.

The paper explores the ambigrammatic sequences in narnaviruses, showing that codon alignment allows for stop codon elimination in the reverse strand through synonymous substitutions, suggesting a mechanism for de novo gene creation.