The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation
Hideyuki Sato, Ayaka Yanagida, Mariko Kasai, Naoaki Mizuno, Eiji Mizutani, Hiromi Yamamoto, Satoko Ishii, Taro Hihara, Kazuto Yamazaki, Ayuko Uchikura, Kazuaki Nakano, Masashi Ito, Hiroshi Nagashima, Hideki Masaki, Hiromitsu Nakauchi
This paper enhances human pluripotent stem cell (hPSC) proliferation to improve chimaerism in human-mouse chimaeras, resulting in viable pups with integrated hPSC-derived tissues.
bioRxiv · Jun 24, 2025 · PreprintDevelopmental Biology