Ayaka Yanagida

Ectopic hAMH-driven SOX17 expression induces hyperplastic Sertoli valve formation in mouse testes

This study shows that ectopic SOX17 in Sertoli cells promotes Sertoli valve formation and partially rescues infertility in Sox17-null mice.

Xenophagocytosis blockade enhances interspecies chimerism

This study identifies xenophagocytosis as an innate immune barrier that limits interspecies chimerism and shows that blocking it enhances donor cell engraftment in mouse embryos.

The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation

This paper enhances human pluripotent stem cell (hPSC) proliferation to improve chimaerism in human-mouse chimaeras, resulting in viable pups with integrated hPSC-derived tissues.

Plakoglobin is a mechanoresponsive regulator of naïve pluripotency

This study shows that Plakoglobin regulates naive pluripotency in mouse ESCs through mechanosensitivity, with expression specific to the blastocyst stage in human and mouse embryos.

Cell surface fluctuations regulate early embryonic lineage sorting

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.

Droplet-based Single-cell Total RNA-seq Reveals Differential Non-Coding Expression and Splicing Patterns during Mouse Development

The paper introduces VASA-seq, a method for total single-cell RNA-seq in mice, revealing non-coding RNA expression and alternative splicing during development.

Human Naive Epiblast Cells Possess Unrestricted Lineage Potential

The paper shows human naive epiblast cells can generate trophectoderm and trophoblast cells, unlike mouse embryonic stem cells, and identifies key regulators of this process.

Oct4 regulates embryonic pluripotency via metabolic mechanisms and Stat3 signalling.

This study identifies OCT4's role in maintaining pluripotency through metabolic regulation and Stat3 signaling in mouse embryos.