Author

Barbara Xiong

University of PennsylvaniaORCID 0000-0002-5202-1095Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Kai TaniD· 2 shared Anusha ThadiiD· 1 shared Changya CheniD· 1 shared Charles Nelson· 1 shared Chia-Hui Chen· 1 shared David Smith· 1 shared Derek Oldridge· 1 shared Gwendolyn Duncan· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Kai TanORCID

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2 papers

Recent·Most cited

N-Orbit: towards a universal model and metric for comparing tissue microenvironments

Barbara Xiong, Yuxuan Hu, Kai Tan

The paper introduces N-Orbit, a mathematical model for comparing tissue microenvironments by encoding cell type composition and spatial relationships, showing improved performance over existing metrics in neighborhood discrimination and clinical prediction.

Nature Communications · May 22, 2026Peer-reviewedBioinformatics

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

Shovik Bandyopadhyay, Michael Duffy, Kyung Jin Ahn, Minxing Pang, David Smith, Gwendolyn Duncan, Jonathan Sussman, Iris Zhang, Jeffrey Huang, Yulieh Lin, Barbara Xiong, Tamjid Imtiaz, Chia-Hui Chen, Anusha Thadi, Changya Chen, , Kai Tan

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

bioRxiv · Mar 14, 2024 · PreprintCell Biology