Restraint of TGFβ family signaling by SMAD7 is necessary for hematopoietic stem cell maturation in the embryo.
Laura F. Bennett, Wenbao Yu, Chia-Hui Chen, Hyun Hyung An, Joanna M. Tober, Kai Tan, Nancy A. Speck
This study shows that SMAD7 restrains TGFβ and BMP signaling to enable pre-HSC maturation into HSCs during embryonic hematopoiesis.
bioRxiv · Aug 23, 2025 · PreprintDevelopmental Biology