SARS-CoV-2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways
Bruno Eduardo da Silva, Rayner Ribeiro Cardoso, Lívia Maria Ribeiro Rosário, João Paulo Prado, Rafaela Silva dos Santos, Flavio Protasio Veras, Mylena de Souza, Eduardo Maffud Cilli, Danilo S. Olivier, Marco Antônio de Andrade Belo, Ives Charlie‐Silva, Ester Siqueira Caixeta, Angel Roberto Barchuk, Albená Nunes-Silva, Thiago Roberto Lima Romero, Giovane Souza Galdino
This study shows SARS-CoV-2 spike peptides trigger pain via spinal TLR4 and microglia, with PSPD2003 inducing inflammation and microglial activation.
European Journal of Pain · Aug 1, 2026Peer-reviewedPharmacology & Toxicology