The rabies virus interferon antagonist P protein selectively modulates interferon signalling to inhibit antiviral gene expression while supporting proviral gene expression
Alebachew Messele, Cassandra T. David, Stephen M. Rawlinson, Céline Deffrasnes, Paul R. Gooley, Samuel C. Forster, Gregory W. Moseley
This paper shows that the rabies virus P protein selectively inhibits certain IFN-stimulated and repressed genes while allowing others, demonstrating that IFN-antagonists can modulate specific pathways rather than globally suppressing IFN signaling.
bioRxiv · Jul 31, 2026 · PreprintSystems Biology